Endocrine Abstracts

IntroductionInsulinoma is the most frequent pancreatic endocrine tumor and is confirmed in case of a hyperinsulinic hypoglycemia with elevated C-peptide and absence of sulfonylureas. Tomodensitometry, MRI, endoscopic ultrasound are the imaging means used to assess localization before surgery as it is not always determined by one mean only, and in a few cases, all means may not determine localization.MethodsTh...

IntroductionSpontaneous hypoglycemia in non-diabetic adults represent a challenge in confirming the organic cause, requiring in that case specific medication or surgery, in a setting of a possible life-threatening disease.MethodsWe conducted a retrospective study of patients admitted in our department for spontaneous hypoglycemia. Functional and factitious etiology were excluded. Clinical and biologic feature...

IntroductionThe empty sella syndrome is a rare disorder characterized by a flattened pituitary gland leaving place to the cerebrospinal fluid to fill in the sella turcica.The diagnosis is radiological and it is often discovered during pituitary disorders. Generally patients suffer from hypopituitarism, and primary hypothyroidism is found to be a rare association.ObservationHerein the case of a young woman who...

IntroductionThe atypical parathyroid adenoma is a histological diagnosis. It is a parathyroid tumor with atypical histological features different from an adenoma and not similar enough to be considered as a carcinoma.It has an uncertain malignant potential.ObservationWe report the case of a 55 year-old woman, referred to us by her rhumatologist after discovering a severe hypercalcemia when exploring her for o...

BackgroundPrimary hyperparathyroidism (PHPT) results from inappropriate overproduction of parathyroid hormone from one or more of parathyroid glands with consequent hypercalcemia. Medical therapy by bisphosphonates is indicated for patients contraindicated for surgical treatment or those with therapy failure. We report the observation of a patient receiving zoledronic acid for persistent PHPT and who developped bisphosphonate-related osteonecrosis of the...

IntroductionPheochromocytoma is rare neuroendocrine tumor arising from the chromaffin cells of the adrenal medulla. It can be even sporadic or take part of inherited syndromes.ObservationWe report the case of a young 32 year-old woman followed by her oncologist for medullary thyroid cancer treated with surgery and radiotherapy. On the examination of the removed tissue, there was a bilateral cancer, measuring ...

IntroductionAutoimmune polyglandular syndrome (APS) is a rare endocrinopathy, characterized by the coexistence of two or more glandular autoimmune diseases that can appear at different intervals of time.ObservationHerein the case of a young woman descendant of first degree consanguineous marriage, diagnosed since the age of six with celiac disease (CD) where gluten-free diet was not respected due to poor soci...

IntroductionAs hypoglycemia is a common symptom, an organic cause is always the first diagnosis looked for as it can be associated with a specific medical or surgical treatment. Diagnosis of functional etiology isn’t as precise, as the whipple triad can be incomplete. We herein report a serie of confirmed etiology for functional hypoglycemia.MethodsThis is a descriptive retrospective study including 20 c...

IntroductionPrimary amenorrhea should be considered in any patient who has not experienced periodic menstruation by 16 years regardless of the presence of normal growth and development of secondary sexual characteristics.Observation17-year-old patient, who exhibited normal secondary sexual characteristics, normal auxiliary and pubic hairs, normal breast development since the age of 12 with the non-appearance ...

IntroductionGrave’s disease is an autoimmune disease characterized by hyperthyroidism. It is in some cases associated to more autoimmune organs dysfunction. The antithyroid drugs are the first line treatement, and sometimes they are responsible for severe adverse effects.ObservationWe report the case of a 34 year-old man, treated for his grave’s disease with thiamazol for two years. Two weeks after ...